Wheat, sugarcane and cotton are the main crops grown in the town and the surrounding district. Rice, jowar, pearl millet, moong bean, masoor, ground nuts, maize, mustard seeds, sunflower seeds, and other oil seeds are grown in the area in small amounts.
Mangoes, dates, citruses, and pomegranates are the main fruits grown in the region. Jamun, pears, phalsa, and bananas are also grown in minor quantities.
Vegetables grown in the area include onions, carrots, cauliflower, peas, okra, turnips, tomatoes, potatoes, garlic and chilies.
Muzaffargarh is a leading district in fish farming, with about 15000 acres of land being utilized for aquaculture. The Indian major carp and the tilapia are the most commonly cultured fish.