The city of Muzaffargarh is located in southern Punjab province at almost the exact centre of Pakistan. The closest major city is Multan. The area around the city is a flat, alluvial plain and is ideal for agriculture, with many citrus and mango farms. There are many canals that cut across the Muzaffargarh District, providing water from nearby farms. This makes the land very fertile. However usually land close to the Chenab are usually flooded in the monsoon season.
Muzaffargarh features an arid climate with very hot summers and mild winters. The city witnesses some of the most extreme weather in the country. The highest recorded temperature is approximately 54 °C (129 °F), and the lowest recorded temperature is approximately −1 °C (30 °F). The average rainfall is roughly 127 millimetres (5.0 in). Dust storms are a common occurrence within the city.