Muzaffargarh connects with other cities through:
Roads
The town is linked to the rest of the district by paved roads that stretch for 983.69 km. Buses for Multan leave frequently, because of their close proximity to each other. There are also buses that travel to more distant destinations. The N-5 National Highway connects the city to the other parts of Pakistan. This highway allows for direct travel to Rawalpindi, Islamabad, Faisalabad, Karachi, Lahore, and Bahawalpur.
Railways
Muzaffargarh is connected by rail with all parts of Pakistan, as it lies on the branch track between Rawalpindi, Multan, Mianwali and Attock. The main Peshawar-Karachi railway line also passes through Multan district.
Airport
Muzaffargarh has no Airport. The people of Muzaffargarh primarily use the Multan International Airport. A rise in air travel in the region has led to the expansion of the airport with a new runway and terminal.